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lolwut.Hyperspeed with my mouse at 1500 dpi.
It lets me turn and look in any direction without having to move my hand - my wrist motions are more stable than my arm motions, and I can make a smooth, uninterrupted, 360-degree rotation. I get the feeling this sort of thing differs from person to person, though.lolwut.
Personally, I'm not a fan of higher sensitivities. Higher sensitivity = a slight movement of my hand out of shock/surprise/whatever could make me completely mess up...it seems like it'd be harder to point at someone...I mean sure, I can start pointing at them quicker, but I also stop pointing at them quicker...maybe that's just me.